Jaguars vs. Broncos: Week 2 opening odds
DENVER, CO - DECEMBER 21: Trevor Lawrence #16 of the Jacksonville Jaguars runs with the football during the third quarter against the Denver Broncos at Empower Field at Mile High on December 21, 2025 in Denver, Colorado. (Photo by Justin Edmonds/Getty Images) | Getty Images

The Jacksonville Jaguars (1-0) will pack up their beach towels and hop on a jet to rocky Colorado to face the Denver Broncos (0-0) at 4:05 p.m. EST on Sunday, Sept. 20.

The Jaguars are fresh off a dominant 34-10 win over the Cleveland Browns; the Broncos will play their first game of the 2026 season tonight on Monday Night Football against the Kansas City Chiefs.

According to FanDuel Sportsbook, the Jaguars are 2.5-point underdogs and the total is set at 44.5 points.

Home-field advantage is typically worth 3 points, so you could say that this would be a pretty even matchup on a neutral field.

But it sounds like Jaguars captains Trevor Lawrence and Josh Hines-Allen are eager to re-prove themselves at Mile High.

“It was awesome to get a win in Week 1,” Lawrence said postgame, “but we have a big challenge next week and got to turn the page and go put together another great game plan.”

“I think there’s a lot to improve from today,” Hines-Allen said. “I can’t wait to watch the tape and improve and get back next week. Got Denver, big challenge for us. We’re looking forward to the matchup, though.”

What are your thoughts on the Jaguars’ Week 2 matchup? Let us know in the comments below!

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